Translating a Regular Grid over a Point Set

We consider the problem of translating a (finite or infinite) square grid G over a set S of n points in the plane in order to maximize some objective function. We say that a grid cell is k-occupied if it contains k or more points of 5. The main set of problems we study have to do with translating an infinite grid so that the number of fe-occupied cells is maximized or minimized. For these problems we obtain running times of the form O(kn polylog n). We also consider the problem of translating a finite size grid, with m cells, in order to maximize the number of fe-occupied cells. Here we obtain a running time of the form O(knm polylog nm)

Approximating Maximum Diameter-Bounded Subgraph in Unit Disk Graphs

We consider a well studied generalization of the maximum clique problem which is defined as follows. Given a graph G on n vertices and an integer d >= 1, in the maximum diameter-bounded subgraph problem (MaxDBS for short), the goal is to find a (vertex) maximum subgraph of G of diameter at most d. For d=1, this problem is equivalent to the maximum clique problem and thus it is NP-hard to approximate it within a factor n^{1-epsilon}, for any epsilon > 0. Moreover, it is known that, for any d >= 2, it is NP-hard to approximate MaxDBS within a factor n^{1/2 - epsilon}, for any epsilon > 0. In this paper we focus on MaxDBS for the class of unit disk graphs. We provide a polynomial-time constant-factor approximation algorithm for the problem. The approximation ratio of our algorithm does not depend on the diameter d. Even though the algorithm itself is simple, its analysis is rather involved. We combine tools from the theory of hypergraphs with bounded VC-dimension, k-quasi planar graphs, fractional Helly theorems and several geometric properties of unit disk graphs

Optimal parallel algorithms for rectilinear link-distance problems

We provide optimal parallel solutions to several link-distance problems set in trapezoided rectilinear polygons. All our main parallel algorithms are deterministic and designed to run on the exclusive read exclusive write parallel random access machine (EREW PRAM). Let P be a trapezoided rectilinear simple polygon with n vertices. In O(log n) time using O(n/log n) processors we can optimally compute: 1. Minimum réctilinear link paths, or shortest paths in the L1 metric from any point in P to all vertices of P. 2. Minimum rectilinear link paths from any segment inside P to all vertices of P. 3. The rectilinear window (histogram) partition of P. 4. Both covering radii and vertex intervals for any diagonal of P. 5. A data structure to support rectilinear link-distance queries between any two points in P (queries can be answered optimally in O(log n) time by uniprocessor). Our solution to 5 is based on a new linear-time sequential algorithm for this problem which is also provided here. This improves on the previously best-known sequential algorithm for this problem which used O(n log n) time and space.5 We develop techniques for solving link-distance problems in parallel which are expected to find applications in the design of other parallel computational geometry algorithms. We employ these parallel techniques, for example, to compute (on a CREW PRAM) optimally the link diameter, the link center, and the central diagonal of a rectilinear polygon

Computing the greedy spanner in near-quadratic time

It is well-known that the greedy algorithm produces high quality spanners and therefore is used in several applications. However, for points in d-dimensional Euclidean space, the greedy algorithm has cubic running time. In this paper we present an algorithm that computes the greedy spanner (spanner computed by the greedy algorithm) for a set of n points from a metric space with bounded doubling dimension in time using space. Since the lower bound for computing such spanners is Ω(n 2), the time complexity of our algorithm is optimal to within a logarithmic factor

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

A simple optimal parallel algorithm for reporting paths in a tree

We present optimal parallel solutions to reporting paths between pairs of nodes in an n-node tree. Our algorithms are deterministic and designed to run on an exclusive read exclusive write parallel random-access machine (EREW PRAM). In particular, we provide a, simple optimal parallel algorithm for pre-processing the input tree such that the path queries can be answered efficiently. Our algorithm for preprocessing runs in O(log n) time using O(n/log n) processors. Using the preprocessing, we can report paths between k node pairs in O(log n + log k) time using O(k + (n + S)/log n) processors on an EREW PRAM, where S is the size of the output. In particular, we can report the path between a single pair of distinct nodes in O(log n) time using O(L/log n) processors, where L denotes the length of the path

I/O-optimal algorithms for outerplanar graphs

We present linear-I/O algorithms for fundamental graph problems on embedded outerplanar graphs. We show that breadth-first search, depth-first search, single-source shortest paths, triangulation, and computing an ε-separator of size O(1/ε) take O(scan(N)) I/Os on embedded outerplanar graphs. We also show that it takes O(sort(N)) I/Os to test whether a given graph is outerplanar and to compute an outerplanar embedding of an outerplanar graph, thereby providing O(sort(N))-I/O algorithms for the above problems if no embedding of the graph is given. As all these problems have linear-time algorithms in internal memory, a simple simulation technique can be used to improve the I/O-complexity of our algorithms from O(sort(N)) to O(perm(N)). We prove matching lower bounds for embedding, breadth-first search, depth-first search, and single-source shortest paths if no embedding is given. Our algorithms for the above problems use a simple linear-I/O time-forward processing algorithm for rooted trees whose vertices are stored in preorder

I/O-Efficient Algorithms for Graphs of Bounded Treewidth

We present an algorithm that takes ON I/Os (sort(N)=Θ((N/(DB)) log∈ M/B (N/B)) is the number of I/Os it takes to sort N data items) to compute a tree decomposition of width at most k, for any graph G of treewidth at most k and size N, where k is a constant. Given such a tree decomposition, we use a dynamic programming framework to solve a wide variety of problems on G in ON DB I/Os, including the single-source shortest path problem and a number of problems that are NP-hard on general graphs. The tree decomposition can also be used to obtain an optimal separator decomposition of G. We use such a decomposition to perform depth-first search in G in ON DB I/Os. As important tools that are used in the tree decomposition algorithm, we introduce flippable DAGs and present an algorithm that computes a perfect elimination ordering of a k-tree in ON. The second contribution of our paper, which is of independent interest, is a general and simple framework for obtaining I/O-efficient algorithms for a number of graph problems that can be solved using greedy algorithms in internal memory. We apply this framework in order to obtain an improved algorithm for finding a maximal matching and the first deterministic I/O-efficient algorithm for finding a maximal independent set of an arbitrary graph. Both algorithms take O. The maximal matching algorithm is used in the tree decomposition algorithm